Amphiphilic block copolymers-based mixed micelles for noninvasive drug delivery
نویسندگان
چکیده
منابع مشابه
Unimolecular micelles of amphiphilic cyclodextrin-core star-like block copolymers for anticancer drug delivery.
Well-defined star-like amphiphilic polymers composed of a β-cyclodextrin core, from which 21 hydrophobic poly(lactic acid) arms and hydrophilic poly(ethylene glycol) arms are grafted sequentially, form robust and uniform unimolecular micelles that are biocompatible and efficient in the delivery of anticancer drugs.
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Delivery of hydrophobic molecules and proteins has been an issue due to poor bioavailability following administration. Thus, micelle carrier systems are being investigated to improve drug solubility and stability. Due to problems with toxicity and immunogenicity, natural polysaccharides are being explored as substitutes for synthetic polymers in the development of new micelle systems. By grafti...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2016
ISSN: 1071-7544,1521-0464
DOI: 10.3109/10717544.2016.1149743